Clokeran 5mg Tablet
Chlorambucil (5mg)
by Natco Pharma Ltd
strip of 30 tablets
About this medicine
Clokeran 5mg Tablet is used in the treatment of some cancers of blood and lymphatic system. It may be also used to treat other kinds of cancer, as determined by the doctor. It is used alone or in combination with other cancer medicines. Clokeran 5mg Tablet should be taken empty stomach, or 1 hour before and 2 hours after a meal. But, try to have it at the same time every day for most benefits. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include anemia (low number of red blood cells), decreased blood cells (red cells, white cells, and platelets) decreased white blood cell count, infection, nausea and vomiting. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Inform your doctor if you have a medical history, of bleeding disorders, heart or liver disease, radiation treatment or any infection. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is known to reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses
- Blood cancer
- Hodgkin’s disease
Benefits
In blood cancer
Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Clokeran 5mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
How it works
Clokeran 5mg Tablet is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
How to use
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clokeran 5mg Tablet is to be taken empty stomach.
Common side effects
- Anemia (low number of red blood cells)
- Decreased blood cells (red cells, white cells, and platelets)
- Decreased white blood cell count (neutrophils)
- Decreased white blood cell count
- Bone marrow suppression
- Nausea
- Vomiting
- Diarrhea
- Mouth ulcer
Safety advice
- AlcoholCONSULT YOUR DOCTOR
- It is not known whether it is safe to consume alcohol with Clokeran 5mg Tablet. Please consult your doctor.
- PregnancyCONSULT YOUR DOCTOR
- Clokeran 5mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
- Breast feedingUNSAFE
- Clokeran 5mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
- DrivingCONSULT YOUR DOCTOR
- It is not known whether Clokeran 5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
- KidneyCAUTION
- Clokeran 5mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Clokeran 5mg Tablet may be needed. Please consult your doctor. Careful monitoring by a doctor is important as kidney disease patients are at an increased risk of bone marrow depression and inflammation and infections of urinary bladder while taking this medicine.
- LiverCONSULT YOUR DOCTOR
- There is limited information available on the use of Clokeran 5mg Tablet in patients with liver disease. Please consult your doctor.
If you miss a dose
If you miss a dose of Clokeran 5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick facts
- Chemical Class
- Nitrogen Mustard Compounds
- Habit Forming
- No
- Therapeutic Class
- Anti neoplastics
- Action Class
- Alkylating agent
Frequently asked questions
How is Clokeran 5mg Tablet administered?
Clokeran 5mg Tablet is administered orally in tablet form.
Why is Clokeran 5mg Tablet toxic to cancer cells/ how does Clokeran 5mg Tablet work?
Clokeran 5mg Tablet belongs to a class of drugs called nitrogen mustard derivatives which kill the cancer cells by interfering with DNA replication, and also by directly slowing or stopping their growth.
Does Clokeran 5mg Tablet cause hair loss/constipation?
No, hair loss or constipation has not been reported with the use of Clokeran 5mg Tablet.
What is Clokeran 5mg Tablet used for?
Clokeran 5mg Tablet is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. It is also used to treat Waldenstrom's macroglobulinaemia (rare blood condition involving the release of an abnormal protein, macroglobulin, into the blood).
How is Clokeran 5mg Tablet excreted?
Clokeran 5mg Tablet is metabolized in liver to form nontoxic compounds which are excreted in urine.
Does Clokeran 5mg Tablet need to be refrigerated?
Clokeran 5mg Tablet has to be stored in a refrigerator at a temperature between 2 °C – 8 °C.
Product details
- Manufacturer
- Natco Pharma Ltd
- Salt composition
- Chlorambucil (5mg)
- Pack
- strip of 30 tablets
- Dosage form
- Tablet
- Storage
- Store in a refrigerator (2 - 8°C). Do not freeze.
The content above is for information only and is not a substitute for professional medical advice, diagnosis or treatment. Always consult a registered medical practitioner before starting, stopping or changing any medicine.